Multiple Sclerosis & Vitamin D
The Vitamin D Hydroxy Blood Test is the recommended test for those purposes. In some cases, the Vitamin D 1,25 Dihydroxy Blood Test is ordered if an abnormality associated with the enzyme that converts hydroxyvitamin D to 1,dihydroxyvitamin D or kidney disease is suspected. Low levels may be indicative of the latter, as this is often. The most accurate way to measure how much vitamin D is in your body is the hydroxy vitamin D blood test. A level of 20 nanograms/milliliter to 50 ng/mL is considered adequate for healthy people.
By now many of you have heard how important vitamin D supplementation is. But the whxt is that so many people are sub-optimal in v vitamin D range that they could take IU for the rest of their life everyday and never budge. Vitamin D is necessary for the health of every cell in the body. In fact, a recent study showed that women with the best vitamin D levels hydrroxy the ones who survived breast cancer bitamin.
So it was very statistically significant. They said preliminary, this is preliminary data only and we need more studies before suggesting that anyone with breast cancer take extra vitamin D. Getting your vitamin D into dhat optimal level has no risks whatsoever. So, since there are so many benefits, why not get your vitamin D level optimal now whether or not you have a disease right now? Those with what is the meaning of fake in hindi highest vitamin D levels have the lowest risk of MS, arteriosclerosis, breast cancer, bowel cancer and just general overall health.
In fact, a brand new study just came out showing that women with low vitamin D levels have the most bacterial vaginosis. If you just get your vitamin D level into the optimal range, guess what? Your vagina will also feel better. And the test that you want to ask for, and this is important, is you need hydroxy vitamin D. Hydroxu could also go to Grassrootshealth. Guess what? So you need a way to supplement with vitamin D. This will push vitamin D into your cells.
By the way, one minute Sun bath over as much of your body as possible will give you 20, IU. The Sun is very, very generous. Most of us are going to need to supplement in addition to sun exposure. By the way, one of my doctor friends drew the blood of a surfer who was out in the Sun in Hawaii all the time. His vitamin D level was How to get dvd cover art you can have it with v combination of a little wise Sun exposure and enough supplementation.
And to me, this is prevention at its finest. Update: www. Plus a huge amount of great science on the viramin. Christiane Northrup, M. Recognizing the unity of body, mind, and spirit, she empowers women to trust their inner wisdom, their connection with Source, and their ability to truly flourish. Reviewed March By now many of you have heard how important vitamin D supplementation is. I know how bad this one feels
Vitamin D oral supplementation and skin synthesis have a different effect on the transport form of vitamin D, plasma calcifediol concentrations. Endogenously synthesized vitamin D 3 travels mainly with vitamin D-binding protein (DBP), which slows hepatic delivery of vitamin D . Dec 18, · And the test that you want to ask for, and this is important, is you need hydroxy vitamin D. So that’s what you ask your health care practitioner to order, hydroxy vitamin D. You could also go to mesmmdaten.com and you don’t need a doctor’s prescription so that you can get your blood ordered that way. Serum hydroxyvitamin D levels may be overused, but when trying to assess vitamin D stores or diagnose vitamin D deficiency (or toxicity), hydroxyvitamin D is the correct test.
Vitamin D is fat soluble vitamin. It helps regulate calcium metabolism. Vitamin D is synthesized by the skin from sunlight. Vitamin D needs to undergo conversion from its inert state by process of hydroxylation initially in the liver. Converting to hydroxyvitamin D 25 OH D and then in the kidney which produces the active form 1,25 dihydroxy vitamin D calcitriol. Vitamin D is also found in certain foods and pill supplements.
A wide array of clinical and basic science literature has established the importance of adequate levels of vitamin D in the prevention of rickets in children, and osteoporosis, osteopenia, hip fracture and osteomalacia in older adults.
In many instances, the link has been established by association, however there is an active body of research conducting randomized clinical trials and establishing causative links. In the United States there is an increased incidence of bone fractures especially in the elderly populations.
Hip fracture is second to stroke as a major cause of disability and nursing home placements. MS patients tend NEU to stay out of the sunlight because of heat sensitivity further increasing the risk for Vitamin D deficiency. There have been studies that suggest Vitamin D deficiency may play a role in immune system function and the development of auto immune disorders such as Multiple Sclerosis.
There has also been increasing evidence that deficiency may also increase risk for developing cardiovascular disease and certain types of cancers- such as uterine, breast, prostate, colon. Animal studies have been able to demonstrate that EAE experimental autoimmune encephalomyelitis could not be elicited in mice that had sufficient Vitamin D levels.
It is theorized that the amount of sunlight exposure affects the production of Vitamin D and the hormonal form of Vitamin D may be a selective immune regulator and potentially could inhibit the development of the disease.
Some studies indicate that relapse rates were decreased in MS patients taking higher oral supplements of Vitamin D but the data is limited. A recent study done in Australia indicates that sunlight exposure and Vitamin D intake may be independent factors affecting risk for CNS demyelination.
There is currently a significant interest in Vitamin D and researchers are continuing to study what role Vitamin D may play in diseases including Multiple Sclerosis. For example, evidence points to the direct and indirect regulation of T cell development and function by vitamin D. In animal models, in the absence of vitamin D and signals delivered through the vitamin D receptor, auto reactive T cells develop and in the presence of active vitamin D 1,25 OH 2 D 3 and a functional vitamin D receptor the balance in the T cell response is restored and autoimmunity avoided.
There is currently no evidence that this vitamin deficiency is the cause of Multiple Sclerosis. There has been increased interest that Vitamin D deficiency is prevalent in areas where there is less sunlight exposure and being further away from the equator in both directions. We also know that Multiple Sclerosis is more often found in northern climates above 40 degrees latititude. The highest incidence of Multiple Sclerosis is found in Scandinavian countries where there is lower sunlight exposure.
The correlation of decreased sunlight and decreased Vitamin D synthesis in immune system function is not fully understood at this time. Many labs do not report Vit D2 or Vit D 3 levels separately.
Some labs do report them separately and then give a total Vit 25 hydroxy level by combining both Vit D2 and D3 scores. Med , 3 This may be higher in Northeastern Ohio. Two sources of Vitamin D: exogenous ingested Vit D from foods and supplements and endogenous from sunlight. Since Vitamin D is fat soluble, toxicity can occur at high levels of oral intake of supplements.
There are no strict guidelines on Vit D supplements, many are anecdotally based. Food sources: Fatty fish such as salmon, mackerel, tuna, sardines. Multiple Sclerosis patients should be considered and especially, marginally ambulatory or nonambulatory patients. Patients with hypercalcemia, hypervitaminosis D, malasorption syndrome, decreased renal function. Caution needs to be exercised with use of Vitamin D supplements in patients with heart disease, renal calculi, or arterosclerosis.
If patients may have hyperparathyroidism they should be evaluated before higher doses of vitamin D supplementation are implemented. Patients stay on this supplement for 4 months and then Vit D hydroxyl level is checked. If the level is nearly normal the dose is increased to IU daily and if quite low then dose is IU daily and make referral to dietician.
Once the Vitamin D level is normal they do not re-check the levels annually. Note that the American Academy of Neurology multiple sclerosis subcommittee recently reviewed literature on Vitamin D deficiency and MS and recommended a wide range of doses from units per day of Vitamin D3.
The current Institute of Medicine recommendations are felt by many doctors to be insufficient to help maintain adequate Vitamin D levels. Supplementation will help prevent loss of bone integrity, decrease risks for fractures There have been patient reports of improvement with fatigue or a decreased perception of pain. Some patients do not have any visible effect but there may be a benefit to immune system function reducing auto immune disorders, cancer and cardiovascular risks.
At the Mellen Center we feel that the preponderance of accumulated data means that we should be focusing on vitamin D supplementation and recommend trying to get patients into the normal range of vitamin D levels unless there are countervailing contraindications. More research is being done and prospective and longitudinal studies may help provide a more comprehensive understanding of any cause and effect relationship of Vitamin D deficiency and immune system functions.
Appointments What is Vitamin D? What are the implications for monitoring Vitamin D? What research has been done to investigate Multiple Sclerosis and Vitamin D deficiency? Is Vitamin D deficiency the cause of Multiple Sclerosis? How is Vitamin D deficiency detected? There are 2 forms that can be detected in the blood: The current recommendation is to order serum OH D Vit D 25 hydroyx.
It has a longer half life and concentration than 1,25 OH-D. It is commonly tested to assess Vitamin D status. It is not affected by PTH parathyroid hormone levels. Vitamin D can be obtained from sunlight exposure min daily exposing both forearms.
Vitamin D 2 or Vitamin D 3 supplements: Food sources: Fatty fish such as salmon, mackerel, tuna, sardines. Who should be considered for Vitamin D deficiency? Elderly patients Patients that have other co-morbidities like cancer, any additional auto immune disorder Endocrine disorders like hyperparathyroidism Patients that have had fractures Any patient on long term steroid Rx African American, Hispanic patients as darker skinned people have decreased absorption of Vitamin D from sunlight exposure Gastric bypass patients Who should not be considered for Vitamin D supplementation?
How is Vitamin D deficiency supplementation dosed? Note that taking Vitamin D with food enhances absorption. What should be taken into consideration prior to starting Vit D supplementation? Pregnant patients, patients planning to become pregnant, nursing mothers - Vit D at 50, IU weekly is pregnancy risk category C dose exceeds RDA Pregnancy risk category A if dose is the recommended RDA and is not exceeded Supplements patients are taking in multivitamins, calcium and OTC Vitamin D Other medication interactions: Antacids may cause hypermagnesemia, Cardiac glycosides may increase risk for arrhythmias, verapamil increase risk for A fib — monitor calcium levels closely.
Corticosteroids may antagonize effect of Vit D. Vitamin D and multiple sclerosis. Lancet Neurology ; 9 6 Banwell B,et al. Incidence of acquired demyelination of the CNS in Canadian children.
Neurology ; Neurology ; 74 23 Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol. Epub Feb Immunomodulatory effects of vitamin D in multiple sclerosis. Brain ; Sun exposure and vitamin D are independent risk factors for CNS demyelination. Neurology ; Evaluation of vitamin D repletion regimens to correct vitamin D status in adults. Endocrine Practice ;15 2 : Pierrot-Deseilligny C.
Clinical implications of a possible role of vitamin D in multiple sclerosis. Journal of Neurology ; Vitamin D as an immune modulator in multiple sclerosis, a review. Journal of Neuroimmunology ; : Multiple Sclerosis and Vitamin D —a review. European Journal of Clinical Nutrition ; Vit D 2 - 50, IU - 1 tab qd x 14 days, then 2 tabs a week x 2 months, then 2 tabs per month on the 1st and 15th.